Negative regulation of lymphocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of lymphocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL3, JAK3, and CD3G, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte mediated immunity activity versus RASAL3 in BRCA (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RASAL3 →	+0.832	+0.214	<.001	<.001	3	10
GBM	JAK3 →	+1.035	+0.353	<.001	<.001	3	10
HNSC	CD3G →	+0.718	+0.201	<.001	<.001	3	10
HNSC	ARRDC5 →	+0.645	+0.278	<.001	<.001	3	10
HNSC	SP140 →	+0.968	+0.296	.001	<.001	3	10
HNSC	IL2RB →	+0.814	+0.238	.003	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002707 vs RASAL3 — BRCA

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