Negative regulation of lymphocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of lymphocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB1, ZEB1, and NAV3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lymphocyte mediated immunity activity versus ITGB1 in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ITGB1 →	+1.608	+0.460	<.001	.005	3	6
LUNG_NSCLC_LUSC	ZEB1 →	+2.540	+0.341	.003	.009	2	7
BONE	NAV3 →	+2.572	+0.388	.005	.004	3	6
LUNG_NSCLC_LUSC	ARHGAP17 →	+1.266	+0.329	.006	.003	3	6
BREAST	GLIPR1 →	+2.155	+0.393	<.001	<.001	3	6
BREAST	ZEB2 →	+1.868	+0.303	.006	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002707 vs ITGB1 — BREAST

Explore this scatter interactively →