Regulation of lymphocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Regulation of lymphocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCRL3, PATL2, and MCOLN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lymphocyte mediated immunity activity versus FCRL3 in CCRCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FCRL3 →	+0.696	+0.187	.005	.002	3	7
BRCA	PATL2 →	+0.489	+0.148	<.001	.004	3	7
LUAD	MCOLN2 →	+0.866	+0.141	<.001	.008	3	6
LUAD	CCR5 →	+0.699	+0.151	.002	.004	3	6
HNSC	CD3G →	+0.812	+0.280	.005	<.001	3	6
HNSC	PRKCB →	+0.614	+0.207	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002706 vs FCRL3 — CCRCC

Explore this scatter interactively →