Positive regulation of leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Positive regulation of leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EVI2A, LCP2, and DOCK8, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte mediated immunity activity versus EVI2A in CHOL (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	EVI2A →	+1.989	+0.035	<.001	.002	3	31
SKCM	LCP2 →	+1.603	+0.033	<.001	<.001	3	31
SKCM	DOCK8 →	+1.627	+0.039	<.001	<.001	3	30
UCS	TNFAIP3 →	+1.762	+0.037	<.001	<.001	3	30
SARC	CYTH4 →	+1.762	+0.035	<.001	<.001	3	30
CHOL	CSF2RB →	+2.343	+0.037	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002705 vs EVI2A — CHOL

Explore this scatter interactively →