Positive regulation of leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Positive regulation of leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGO1, GRP, and CYB5D2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte mediated immunity activity versus SGO1 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SGO1 →	+0.549	+0.245	.006	.003	2	6
BRCA	GRP →	-1.286	-0.218	<.001	.003	3	5
BRCA	CYB5D2 →	-0.656	-0.230	.007	.001	3	5
LUAD	CD7 →	+0.739	+0.181	.001	.001	3	5
BRCA	PRKG1 →	-0.610	-0.214	<.001	.003	3	5
LUAD	POLQ →	+0.973	+0.196	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002705 vs SGO1 — BRCA

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