Negative regulation of leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, SASH3, and SERPINB9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte mediated immunity activity versus RCSD1 in LSCC (Pearson r = 0.78).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.681	+0.092	<.001	<.001	3	10
LSCC	SASH3 →	+0.567	+0.103	<.001	<.001	3	10
LSCC	SERPINB9 →	+0.588	+0.096	<.001	<.001	3	10
HNSC	ATG7 →	+0.288	+0.077	<.001	<.001	3	10
GBM	SKAP2 →	+0.888	+0.095	<.001	<.001	3	10
LSCC	SPN_S355 →	+0.873	+0.085	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002704 vs RCSD1 — LSCC

Explore this scatter interactively →