Negative regulation of leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZEB1, WDR44, and CTSL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte mediated immunity activity versus ZEB1 in OESOPHAGUS (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZEB1 →	+1.902	+0.329	.002	.001	3	6
BLOOD_Lymphoma	WDR44 →	+1.230	+0.269	<.001	<.001	3	6
LUNG_NSCLC_LUSC	CTSL →	+2.674	+0.347	<.001	.003	3	6
BREAST	GLIPR1 →	+2.260	+0.393	<.001	<.001	3	6
URINARY_TRACT	DCBLD1 →	+1.649	+0.478	.003	.008	3	5
OESOPHAGUS	STX2 →	+1.435	+0.306	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002704 vs ZEB1 — OESOPHAGUS

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