Regulation of leukocyte mediated immunity

Across TCGA patient cohorts, RNA activity of the Regulation of leukocyte mediated immunity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, SASH3, and SEPTIN1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte mediated immunity activity versus RCSD1_S351 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RCSD1_S351 →	+0.641	+0.030	<.001	<.001	3	10
GBM	SASH3 →	+0.573	+0.064	<.001	<.001	3	10
HNSC	SEPTIN1 →	+0.858	+0.054	<.001	<.001	3	10
BRCA	SERPINB9 →	+0.531	+0.028	<.001	<.001	3	10
GBM	SKAP2 →	+0.928	+0.070	<.001	<.001	3	10
OV	SPN →	+0.870	+0.037	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002703 vs RCSD1_S351 — BRCA

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