Regulation of leukocyte mediated immunity

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte mediated immunity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF517, CLUAP1, and SDC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF517 grouped by Regulation of leukocyte mediated immunity-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF517 →	-0.669	-0.126	<.001	<.001	3	4
OESOPHAGUS	CLUAP1 →	-0.768	-0.156	.002	.001	3	3
LUNG_NSCLC_LUAD	SDC3 →	-0.962	-0.463	.006	.007	3	3
OESOPHAGUS	NPIPA7 →	-0.873	-0.144	.001	.001	3	3
OESOPHAGUS	MCUR1 →	-0.552	-0.121	.002	.003	3	3
PANCREAS	SH3D19 →	+1.102	+0.953	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF517 by Regulation of leukocyte mediated immunity activity — BLOOD_Leukemia

Explore this box plot interactively →