Positive regulation of production of molecular mediator of immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of production of molecular mediator of immune response pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRHR2, BCL7A, and COA5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRHR2 grouped by Positive regulation of production of molecular mediator of immune response-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CRHR2 →	-0.028	-0.155	.005	.001	3	3
SKIN	BCL7A →	+1.238	+0.167	.001	.008	3	3
LIVER	COA5 →	-0.915	-0.221	.003	.002	3	3
LUNG_NSCLC_LUAD	DHRS4 →	-0.686	-0.156	<.001	<.001	3	3
STOMACH	MCM4 →	+0.644	+0.193	.003	.002	3	3
STOMACH	SORBS3 →	+1.233	+0.224	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRHR2 by Positive regulation of production of molecular mediator of immune response activity — SKIN

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