Positive regulation of production of molecular mediator of immune response

Across TCGA cell cohorts, RNA activity of the Positive regulation of production of molecular mediator of immune response pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPC1, GALNT2, and LOXL2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of production of molecular mediator of immune response activity versus GPC1 in BONE (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GPC1 →	+2.935	+0.335	<.001	<.001	3	7
BLOOD_Lymphoma	GALNT2 →	+2.376	+0.271	<.001	.001	3	7
BONE	LOXL2 →	+5.223	+0.335	<.001	<.001	3	6
BONE	MYB →	-2.277	-0.352	.005	.002	3	6
BREAST	KIFC3 →	+2.137	+0.187	.002	.003	3	6
URINARY_TRACT	PAPSS2 →	+3.481	+0.293	.004	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002702 vs GPC1 — BONE

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