Negative regulation of production of molecular mediator of immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of production of molecular mediator of immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DRAM2, EPB41L1, and CLCC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DRAM2 grouped by Negative regulation of production of molecular mediator of immune response-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DRAM2 →	+2.032	+1.629	.002	.002	3	4
URINARY_TRACT	EPB41L1 →	+2.760	+1.503	.009	<.001	3	4
OESOPHAGUS	CLCC1 →	+0.672	+0.950	.009	.005	2	5
OESOPHAGUS	TMEM222 →	-0.585	-1.152	.001	.002	3	4
CNS	TTC5 →	+0.602	+0.968	<.001	<.001	3	4
LUNG_NSCLC_LUAD	LRFN3 →	+0.728	+0.813	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DRAM2 by Negative regulation of production of molecular mediator of immune response activity — BLOOD_Myeloma

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