Negative regulation of production of molecular mediator of immune response

Across TCGA cell cohorts, RNA activity of the Negative regulation of production of molecular mediator of immune response pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BST2, POU2F1, and TPP2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of production of molecular mediator of immune response activity versus BST2 in SOFT_TISSUE (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BST2 →	+5.403	+2.444	.003	.007	3	12
BLOOD_Leukemia	POU2F1 →	-0.646	-1.094	.004	.006	3	5
BLOOD_Leukemia	TPP2 →	-0.599	-1.108	<.001	<.001	3	5
BLOOD_Leukemia	SPAG5 →	-0.515	-0.952	.002	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ALMS1 →	-0.810	-1.316	.002	.003	3	4
BLOOD_Lymphoma	PRKDC →	-0.965	-0.736	.002	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002701 vs BST2 — SOFT_TISSUE

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