Regulation of production of molecular mediator of immune response

Across TCGA cell cohorts, RNA activity of the Regulation of production of molecular mediator of immune response pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TXNDC16, RNLS, and YME1L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TXNDC16 grouped by Regulation of production of molecular mediator of immune response-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TXNDC16 →	-0.895	-0.167	.004	.005	3	4
LARGE_INTESTINE	RNLS →	-1.770	-0.122	<.001	.003	3	3
STOMACH	YME1L1 →	+0.593	+0.155	<.001	.009	3	3
STOMACH	ALAD →	-0.983	-0.214	<.001	.003	3	3
STOMACH	PGAM1 →	+0.946	+0.185	.001	.001	3	3
STOMACH	FBXO34 →	-1.603	-0.257	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TXNDC16 by Regulation of production of molecular mediator of immune response activity — LUNG_NSCLC_LUSC

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