Regulation of production of molecular mediator of immune response

Across TCGA cell cohorts, RNA activity of the Regulation of production of molecular mediator of immune response pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALNT2, PSMB9, and AVPI1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of production of molecular mediator of immune response activity versus GALNT2 in BLOOD_Lymphoma (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GALNT2 →	+2.900	+0.363	.001	.002	3	7
BONE	PSMB9 →	+4.782	+0.366	.001	<.001	3	7
CNS	AVPI1 →	+1.064	+0.285	.004	.003	3	6
BREAST	NLRC5 →	+1.737	+0.231	<.001	<.001	3	6
BLOOD_Lymphoma	FLNA →	+2.038	+0.354	<.001	<.001	3	6
BREAST	IFIT3 →	+1.980	+0.203	.006	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002700 vs GALNT2 — BLOOD_Lymphoma

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