Positive regulation of immune effector process

Across TCGA patient cohorts, RNA activity of the Positive regulation of immune effector process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK4_S1620, PLAUR, and REPS2_T479, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of immune effector process activity versus DOCK4_S1620 in OV (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOCK4_S1620 →	+1.375	+0.179	<.001	.003	3	2
COAD	PLAUR →	+0.707	+0.225	<.001	<.001	3	2
COAD	REPS2_T479 →	-0.321	-0.121	.002	.004	3	1
COAD	ARRB1_T410 →	-0.816	-0.253	<.001	<.001	3	1
COAD	RNGTT →	+0.540	+0.184	.001	.002	3	1
COAD	RPS6KA3_T365 →	-0.309	-0.144	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002699 vs DOCK4_S1620 — OV

Explore this scatter interactively →