Negative regulation of immune effector process

Across TCGA cell cohorts, RNA activity of the Negative regulation of immune effector process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHLDA1, RFLNB, and MXD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PHLDA1 grouped by Negative regulation of immune effector process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PHLDA1 →	+2.285	+1.096	<.001	<.001	3	4
OVARY	RFLNB →	+2.074	+0.752	<.001	.006	3	4
LIVER	MXD3 →	-1.271	-1.254	.001	.007	3	4
URINARY_TRACT	CENPA →	-1.057	-1.496	<.001	.008	3	4
LIVER	USP20 →	-1.254	-1.824	<.001	<.001	3	3
LUNG_NSCLC_LUSC	BRD3 →	-0.753	-1.463	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PHLDA1 by Negative regulation of immune effector process activity — OVARY

Explore this box plot interactively →