Negative regulation of immune effector process

Across TCGA cell cohorts, RNA activity of the Negative regulation of immune effector process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGALS1, FRAT2, and PMP22, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of immune effector process activity versus LGALS1 in BONE (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LGALS1 →	+4.453	+0.373	.004	.005	2	9
OVARY	FRAT2 →	-1.497	-0.449	.001	.001	3	8
LUNG_NSCLC_LUAD	PMP22 →	+1.723	+0.181	.004	.006	3	8
BLOOD_Leukemia	ZYX →	+2.709	+0.369	.001	<.001	3	8
OVARY	BIRC2 →	+1.267	+0.506	<.001	<.001	2	8
BREAST	OPTN →	+2.519	+0.445	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002698 vs LGALS1 — BONE

Explore this scatter interactively →