Positive regulation of cellular extravasation

Across TCGA cell cohorts, RNA activity of the Positive regulation of cellular extravasation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL1R1, B4GALNT4, and GOLGA4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL1R1 grouped by Positive regulation of cellular extravasation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	IL1R1 →	-0.354	-1.486	.009	.003	3	5
LARGE_INTESTINE	B4GALNT4 →	-0.183	-1.316	.004	.005	3	5
BLOOD_Leukemia	GOLGA4 →	-0.315	-1.336	.001	<.001	3	4
PANCREAS	AGAP5 →	+0.154	+1.148	<.001	.002	3	4
LARGE_INTESTINE	LYVE1 →	-0.341	-1.428	<.001	.002	3	4
STOMACH	ADAM8 →	-0.245	-1.182	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL1R1 by Positive regulation of cellular extravasation activity — BONE

Explore this box plot interactively →