Regulation of cellular extravasation

Across TCGA patient cohorts, RNA activity of the Regulation of cellular extravasation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRDM8, PRKCB, and BTN3A3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular extravasation activity versus PRDM8 in GBM (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRDM8 →	+0.724	+0.369	<.001	<.001	3	6
GBM	PRKCB →	+0.827	+0.349	<.001	<.001	3	6
LUAD	BTN3A3 →	+0.373	+0.126	<.001	.005	2	6
LSCC	NCF1B →	+0.489	+0.391	.001	.002	3	5
PDAC	CTNNA3 →	+0.253	+0.205	.001	.002	3	5
UCEC	CLEC4E →	+1.015	+0.276	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002691 vs PRDM8 — GBM

Explore this scatter interactively →