Regulation of cellular extravasation

Across TCGA cell cohorts, RNA activity of the Regulation of cellular extravasation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTX3, BDP1, and EDRF1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular extravasation activity versus MTX3 in BONE (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MTX3 →	-0.750	-0.139	.001	<.001	3	7
LARGE_INTESTINE	BDP1 →	-0.589	-0.073	<.001	.001	3	7
BLOOD_Lymphoma	EDRF1 →	-1.021	-0.067	<.001	<.001	3	7
BLOOD_Lymphoma	SREK1 →	-0.947	-0.084	<.001	<.001	3	7
BREAST	MDK →	+3.261	+0.107	<.001	<.001	3	6
PANCREAS	TCERG1 →	-0.632	-0.134	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002691 vs MTX3 — BONE

Explore this scatter interactively →