Regulation of cellular extravasation

Across TCGA cell cohorts, RNA activity of the Regulation of cellular extravasation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ICAM1, CD99, and CCN1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular extravasation activity versus ICAM1 in OVARY (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ICAM1 →	+3.482	+0.986	.003	.009	3	9
BLOOD_Lymphoma	CD99 →	+2.565	+0.477	.005	.001	2	8
BONE	CCN1 →	+4.974	+0.598	.001	.004	3	7
BONE	HEG1 →	+4.705	+0.689	<.001	<.001	3	7
BONE	HNRNPA1 →	-1.024	-0.622	.001	.001	3	7
BONE	OSMR →	+3.268	+0.562	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002691 vs ICAM1 — OVARY

Explore this scatter interactively →