Positive regulation of leukocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB14, IGF2, and THAP3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ASB14 grouped by Positive regulation of leukocyte chemotaxis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ASB14 →	-0.203	-0.473	.003	.005	3	3
STOMACH	IGF2 →	+4.838	+0.225	.008	<.001	3	3
BLOOD_Leukemia	THAP3 →	+0.537	+0.667	.001	.003	3	2
LARGE_INTESTINE	C3orf62 →	-0.731	-0.456	<.001	.007	3	2
SKIN	PRKAB2 →	-0.488	-0.697	.008	.005	3	2
SKIN	TSC1 →	-0.395	-0.613	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ASB14 by Positive regulation of leukocyte chemotaxis activity — LARGE_INTESTINE

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