Positive regulation of leukocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB8B, PI4K2B, and TTC19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte chemotaxis activity versus RAB8B in BLOOD_Leukemia (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAB8B →	+1.247	+0.217	.001	.002	3	6
BLOOD_Leukemia	PI4K2B →	+0.545	+0.170	.004	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	TTC19 →	+1.046	+0.216	.002	.002	2	6
BONE	ADCK2 →	+1.366	+0.220	.007	.008	3	5
BLOOD_Leukemia	LANCL1 →	+0.765	+0.140	<.001	.007	3	5
OVARY	NFKB1 →	+0.760	+0.312	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002690 vs RAB8B — BLOOD_Leukemia

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