Negative regulation of leukocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RIN3, WIPF1, and WRNIP1_S65, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte chemotaxis activity versus RIN3 in LSCC (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RIN3 →	+0.439	+0.109	<.001	<.001	3	10
HNSC	WIPF1 →	+0.386	+0.057	<.001	<.001	3	10
LSCC	WRNIP1_S65 →	-1.138	-0.089	<.001	<.001	3	9
LSCC	TBC1D2B →	+0.362	+0.100	<.001	<.001	3	9
OV	MRC2 →	+0.740	+0.077	<.001	<.001	3	9
BRCA	PDGFRB →	+0.503	+0.061	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002689 vs RIN3 — LSCC

Explore this scatter interactively →