Negative regulation of leukocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STAU2, GPAA1, and SDC4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STAU2 grouped by Negative regulation of leukocyte chemotaxis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STAU2 →	-1.417	-2.035	.002	<.001	3	6
SKIN	GPAA1 →	-0.529	-0.866	.001	.009	3	6
LIVER	SDC4 →	+1.678	+1.425	.005	.004	3	5
STOMACH	TNIP1 →	+0.977	+1.350	.005	<.001	3	5
LUNG_NSCLC_LUAD	LYSMD1 →	-1.081	-1.136	<.001	<.001	3	5
STOMACH	IFI6 →	+3.238	+1.415	.007	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STAU2 by Negative regulation of leukocyte chemotaxis activity — BLOOD_Lymphoma

Explore this box plot interactively →