Regulation of leukocyte chemotaxis

Across TCGA patient cohorts, RNA activity of the Regulation of leukocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAML, ABI3, and SELPLG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte chemotaxis activity versus JAML in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	JAML →	+0.773	+0.174	<.001	<.001	3	8
GBM	ABI3 →	+0.618	+0.126	<.001	<.001	3	7
GBM	SELPLG →	+0.692	+0.110	<.001	.002	3	7
GBM	TYROBP →	+0.952	+0.166	<.001	<.001	3	7
GBM	CSF3R →	+1.037	+0.175	<.001	<.001	3	7
GBM	CCRL2 →	+0.762	+0.158	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002688 vs JAML — GBM

Explore this scatter interactively →