Regulation of leukocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSC1, TBC1D3L, and SLC25A37, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSC1 grouped by Regulation of leukocyte chemotaxis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TSC1 →	-0.386	-0.681	.006	.003	3	3
CNS	TBC1D3L →	+0.968	+0.662	<.001	.002	3	3
BLOOD_Myeloma	SLC25A37 →	+1.076	+1.052	<.001	.002	3	3
LUNG_NSCLC_LUAD	H2AX →	-0.607	-0.531	.009	.003	3	3
UPPER_AERODIGESTIVE_TRACT	AK2 →	-0.972	-0.197	.008	.005	3	3
PANCREAS	ACVR1B →	-0.514	-0.164	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSC1 by Regulation of leukocyte chemotaxis activity — SKIN

Explore this box plot interactively →