Regulation of leukocyte chemotaxis

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACO2, HDAC1, and RPA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte chemotaxis activity versus ACO2 in LIVER (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ACO2 →	+0.889	+0.270	.003	.003	3	6
BLOOD_Lymphoma	HDAC1 →	+1.081	+0.150	.004	.002	3	5
LARGE_INTESTINE	RPA1 →	+0.798	+0.244	.005	.002	3	5
BONE	NT5M →	+1.430	+0.264	.003	.002	2	6
URINARY_TRACT	ZNF266 →	+1.188	+0.233	.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	PPP1R3E →	+1.448	+0.226	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002688 vs ACO2 — LIVER

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