Positive regulation of leukocyte migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte migration pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUZ12, MPG, and TEAD1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SUZ12 grouped by Positive regulation of leukocyte migration-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SUZ12 →	-0.350	-0.124	.001	<.001	3	7
BREAST	MPG →	-0.253	-0.087	<.001	.005	3	6
LIVER	TEAD1 →	+0.716	+0.150	.002	.002	3	6
SOFT_TISSUE	TP73 →	+0.228	+0.143	.004	<.001	3	6
LARGE_INTESTINE	IBTK →	-0.153	-0.092	.007	<.001	3	5
LUNG_SCLC	CXCL6 →	-0.255	-0.135	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SUZ12 by Positive regulation of leukocyte migration activity — OVARY

Explore this box plot interactively →