Positive regulation of leukocyte migration

Across TCGA cell cohorts, RNA activity of the Positive regulation of leukocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASA2, SLC9A9, and CD274, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte migration activity versus RASA2 in LUNG_SCLC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RASA2 →	+0.802	+0.277	<.001	<.001	3	7
BLOOD_Lymphoma	SLC9A9 →	+1.420	+0.247	.005	<.001	3	6
BLOOD_Lymphoma	CD274 →	+2.032	+0.135	.009	.009	3	6
LUNG_NSCLC_LUAD	LRPPRC →	-0.517	-0.145	<.001	.006	2	7
LUNG_NSCLC_LUAD	DUSP10 →	+1.526	+0.215	.002	.001	3	6
PANCREAS	LMO7 →	+2.178	+0.260	.002	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002687 vs RASA2 — LUNG_SCLC

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