Negative regulation of leukocyte migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL16, HCLS1, and PIP4K2A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte migration activity versus IL16 in OV (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IL16 →	+0.592	+0.047	<.001	<.001	3	10
GBM	HCLS1 →	+0.550	+0.044	<.001	<.001	3	10
OV	PIP4K2A →	+0.399	+0.031	<.001	<.001	3	10
LSCC	RCSD1 →	+0.537	+0.072	<.001	<.001	3	9
UCEC	RIN3 →	+0.424	+0.054	<.001	<.001	3	9
LSCC	SIPA1_S55 →	+0.706	+0.102	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002686 vs IL16 — OV

Explore this scatter interactively →