Negative regulation of leukocyte migration

Across TCGA patient cohorts, RNA activity of the Negative regulation of leukocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGAX, RBMS1P1, and IRAK3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte migration activity versus ITGAX in UCEC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGAX →	+0.893	+0.209	<.001	<.001	3	5
UCEC	RBMS1P1 →	+0.733	+0.205	.009	.004	3	5
UCEC	IRAK3 →	+1.074	+0.265	<.001	<.001	3	5
UCEC	GEMIN2 →	-0.304	-0.127	.006	.005	3	5
LSCC	LILRB3 →	+0.775	+0.508	<.001	<.001	3	5
LSCC	YEATS4 →	-0.877	-0.352	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002686 vs ITGAX — UCEC

Explore this scatter interactively →