Negative regulation of leukocyte migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR19, STEAP3, and OMA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR19 grouped by Negative regulation of leukocyte migration-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WDR19 →	-1.067	-1.108	.006	.004	2	6
CNS	STEAP3 →	+1.352	+0.981	.002	<.001	3	5
STOMACH	OMA1 →	-0.791	-0.966	.001	.001	3	4
STOMACH	STK17A →	+0.859	+0.969	.002	.001	3	4
KIDNEY	FAM126A →	+1.428	+0.837	<.001	.005	3	4
LUNG_NSCLC_LUSC	SQLE →	-1.016	-1.249	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR19 by Negative regulation of leukocyte migration activity — STOMACH

Explore this box plot interactively →