Negative regulation of leukocyte migration

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNC1, ELK3, and TPM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte migration activity versus BNC1 in OVARY (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	BNC1 →	-1.436	-0.166	.002	.007	3	6
BLOOD_Leukemia	ELK3 →	-1.196	-0.173	.003	.002	3	6
SKIN	TPM2 →	-3.356	-0.371	<.001	<.001	3	5
LUNG_NSCLC_LUSC	MDFI →	-3.732	-0.281	<.001	.002	2	6
LUNG_NSCLC_LUSC	PRPF3 →	+1.254	+0.310	.004	.005	3	5
BREAST	MIA3 →	+1.320	+0.322	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002686 vs BNC1 — OVARY

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