Regulation of leukocyte migration

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDFIC, ACTN1, and PRMT9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte migration activity versus MDFIC in BLOOD_Lymphoma (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MDFIC →	+1.707	+0.157	.007	<.001	3	7
BREAST	ACTN1 →	+1.174	+0.144	.005	.004	3	7
LUNG_NSCLC_LUSC	PRMT9 →	+0.519	+0.194	.005	<.001	3	5
SKIN	SLC31A2 →	+1.097	+0.147	.007	.002	3	5
SKIN	GUCD1 →	+0.456	+0.126	.007	.001	3	5
STOMACH	LRPPRC →	-0.888	-0.282	.009	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002685 vs MDFIC — BLOOD_Lymphoma

Explore this scatter interactively →