Negative regulation of acute inflammatory response

Across TCGA cell cohorts, RNA activity of the Negative regulation of acute inflammatory response pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are PD173074, UNC1215, and Luminespib, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PD173074 grouped by Negative regulation of acute inflammatory response-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PD173074 →	-0.610	-0.343	.011	.007	3	1
BLOOD_Leukemia	UNC1215 →	-0.200	-0.343	.010	.007	3	1
BLOOD_Leukemia	Luminespib →	-0.449	-0.343	.007	.007	3	1
BLOOD_Leukemia	123829 →	-0.955	-0.343	.018	.007	3	1
BLOOD_Leukemia	Quizartinib →	+0.482	+0.343	.014	.007	3	1
BLOOD_Lymphoma	Dasatinib →	+1.066	+0.297	.021	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PD173074 by Negative regulation of acute inflammatory response activity — BLOOD_Leukemia

Explore this box plot interactively →