Positive regulation of T cell tolerance induction

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell tolerance induction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GZMB, APOL3, and THEMIS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell tolerance induction activity versus GZMB in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GZMB →	+2.305	+0.513	<.001	<.001	3	7
HNSC	APOL3 →	+1.152	+0.813	<.001	<.001	3	7
GBM	THEMIS2 →	+0.761	+0.399	<.001	<.001	3	7
OV	IDO1 →	+2.097	+0.535	<.001	<.001	3	7
BRCA	GZMA →	+1.416	+0.402	<.001	.005	3	7
BRCA	GZMH →	+1.274	+0.467	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002666 vs GZMB — BRCA

Explore this scatter interactively →