Positive regulation of T cell tolerance induction

Across TCGA patient cohorts, RNA activity of the Positive regulation of T cell tolerance induction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IDO1, APOL3, and STAT1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of T cell tolerance induction activity versus IDO1 in OV (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IDO1 →	+1.180	+0.617	<.001	.003	1	8
BRCA	APOL3 →	+0.691	+0.346	<.001	.002	3	6
LSCC	STAT1 →	+0.766	+0.738	<.001	<.001	3	5
BRCA	TAP1 →	+0.691	+0.338	<.001	<.001	3	5
BRCA	WARS1_S4 →	+1.982	+0.727	<.001	<.001	3	5
LUAD	GBP2 →	+0.602	+0.569	<.001	.006	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002666 vs IDO1 — OV

Explore this scatter interactively →