Positive regulation of T cell tolerance induction

Across TCGA cell cohorts, RNA activity of the Positive regulation of T cell tolerance induction pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPA6, MARK2, and CLVS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPA6 grouped by Positive regulation of T cell tolerance induction-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CPA6 →	-0.181	-0.606	.006	.009	3	5
LIVER	MARK2 →	+0.318	+0.447	.009	.008	2	5
BONE	CLVS2 →	-0.446	-2.313	.002	<.001	3	4
BONE	LRRC15 →	-0.272	-2.302	.002	<.001	3	4
BONE	BCS1L →	-0.150	-1.594	.008	.004	3	4
BLOOD_Myeloma	ITGAV →	+0.376	+1.163	.003	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPA6 by Positive regulation of T cell tolerance induction activity — CNS

Explore this box plot interactively →