Positive regulation of tolerance induction

Across TCGA cell cohorts, RNA activity of the Positive regulation of tolerance induction pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD3E, LILRB2, and LILRB4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD3E grouped by Positive regulation of tolerance induction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CD3E →	-0.197	-0.741	.002	.006	3	6
PANCREAS	LILRB2 →	-0.521	-1.480	.003	.005	1	7
BREAST	LILRB4 →	-0.330	-1.190	.007	<.001	3	5
LUNG_NSCLC_LUAD	TGFBR2 →	-0.104	-0.938	.006	<.001	2	6
KIDNEY	RFX1 →	+0.361	+1.550	<.001	<.001	3	5
STOMACH	KCTD10 →	-0.158	-1.140	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD3E by Positive regulation of tolerance induction activity — BREAST

Explore this box plot interactively →