Positive regulation of tolerance induction

Across TCGA cell cohorts, RNA activity of the Positive regulation of tolerance induction pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHKA, ZNF439, and C6orf132, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHKA grouped by Positive regulation of tolerance induction-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CHKA →	-1.805	-1.425	.007	<.001	3	5
BLOOD_Lymphoma	ZNF439 →	-2.632	-1.528	<.001	.005	3	4
OVARY	C6orf132 →	-1.758	-0.879	.006	.003	3	4
LUNG_NSCLC_LUSC	UIMC1 →	+0.958	+1.253	<.001	.007	3	4
SKIN	FAF2 →	+0.454	+1.087	.007	.002	3	3
SKIN	HCST →	+0.267	+0.987	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHKA by Positive regulation of tolerance induction activity — LIVER

Explore this box plot interactively →