Positive regulation of tolerance induction

Across TCGA cell cohorts, RNA activity of the Positive regulation of tolerance induction pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX4I1, BIRC8, and MYF5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX4I1 grouped by Positive regulation of tolerance induction-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	COX4I1 →	-0.273	-1.753	.005	.002	3	4
BONE	BIRC8 →	-0.368	-1.753	.003	.002	3	4
LUNG_SCLC	MYF5 →	-0.241	-1.775	.004	.002	3	4
BONE	PDIA3 →	+0.339	+2.357	<.001	<.001	3	4
BONE	LRRC15 →	-0.280	-2.337	.002	<.001	3	4
BONE	TRAPPC4 →	-0.271	-2.357	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX4I1 by Positive regulation of tolerance induction activity — BONE

Explore this box plot interactively →