Regulation of tolerance induction

Across TCGA patient cohorts, RNA activity of the Regulation of tolerance induction pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB2, FGD2, and TLR8, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tolerance induction activity versus LILRB2 in SKCM (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LILRB2 →	+1.891	+0.116	<.001	<.001	3	34
SKCM	FGD2 →	+1.530	+0.118	<.001	<.001	3	34
DLBC	TLR8 →	+2.602	+0.159	<.001	<.001	3	33
SKCM	LILRB1 →	+1.940	+0.115	<.001	<.001	3	33
SKCM	IL10RA →	+2.177	+0.117	<.001	<.001	3	33
SKCM	PLEK →	+2.456	+0.120	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002643 vs LILRB2 — SKCM

Explore this scatter interactively →