Regulation of tolerance induction

Across TCGA patient cohorts, RNA activity of the Regulation of tolerance induction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, TRPM2_S38, and WDFY4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tolerance induction activity versus STK10 in LSCC (Pearson r = 0.68).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	STK10 →	+0.433	+0.129	<.001	<.001	3	10
LSCC	TRPM2_S38 →	+0.855	+0.107	<.001	<.001	3	10
HNSC	WDFY4 →	+0.612	+0.110	<.001	<.001	3	10
CCRCC	CCDC88B_S597 →	+0.876	+0.120	<.001	<.001	3	10
HNSC	DOCK10 →	+0.562	+0.132	<.001	<.001	3	10
HNSC	DOCK8 →	+0.583	+0.122	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002643 vs STK10 — LSCC

Explore this scatter interactively →