Regulation of tolerance induction

Across TCGA patient cohorts, RNA activity of the Regulation of tolerance induction pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL3, CCL5, and GZMA, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of tolerance induction activity versus RASAL3 in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASAL3 →	+0.623	+0.657	<.001	<.001	3	8
OV	CCL5 →	+1.347	+0.542	.002	.005	3	8
HNSC	GZMA →	+1.382	+0.869	<.001	.001	3	7
BRCA	TNFRSF8 →	+0.386	+0.461	<.001	<.001	3	7
UCEC	SPI1 →	+0.557	+0.351	.008	.002	3	7
OV	GZMH →	+1.232	+0.500	<.001	.007	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002643 vs RASAL3 — LSCC

Explore this scatter interactively →