Regulation of tolerance induction

Across TCGA cell cohorts, RNA activity of the Regulation of tolerance induction pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RSAD2, MICALL1, and RIPK4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RSAD2 grouped by Regulation of tolerance induction-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RSAD2 →	-1.578	-1.356	.009	.008	3	5
BLOOD_Myeloma	MICALL1 →	+0.692	+1.474	.004	<.001	3	4
SOFT_TISSUE	RIPK4 →	-2.536	-1.455	.002	<.001	3	4
KIDNEY	WDR1 →	-0.683	-0.978	.008	.004	3	4
BLOOD_Leukemia	TSPAN15 →	-1.233	-0.987	.006	.008	3	4
LUNG_SCLC	PTPRG →	-1.538	-1.097	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RSAD2 by Regulation of tolerance induction activity — STOMACH

Explore this box plot interactively →