Positive regulation of immunoglobulin production

Across TCGA cell cohorts, RNA activity of the Positive regulation of immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXER1, WTIP, and MOAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OXER1 grouped by Positive regulation of immunoglobulin production-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OXER1 →	+1.418	+0.182	.001	.005	3	4
BLOOD_Myeloma	WTIP →	+0.464	+0.272	.002	<.001	3	4
LUNG_NSCLC_LUAD	MOAP1 →	+0.543	+0.140	<.001	.002	3	3
LIVER	ZEB1 →	-1.708	-0.270	.006	.004	3	3
SOFT_TISSUE	TTLL7 →	+2.817	+0.188	<.001	.003	3	3
SOFT_TISSUE	PPA2 →	-0.957	-0.290	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OXER1 by Positive regulation of immunoglobulin production activity — SOFT_TISSUE

Explore this box plot interactively →