Positive regulation of immunoglobulin production

Across TCGA cell cohorts, RNA activity of the Positive regulation of immunoglobulin production pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL17RC, SEPTIN9, and TBC1D16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of immunoglobulin production activity versus IL17RC in BLOOD_Lymphoma (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IL17RC →	+1.196	+0.188	.004	.006	3	6
BLOOD_Leukemia	SEPTIN9 →	+1.875	+0.179	<.001	<.001	3	5
SOFT_TISSUE	TBC1D16 →	+0.793	+0.195	.007	.002	3	5
UPPER_AERODIGESTIVE_TRACT	FECH →	+1.061	+0.236	.004	.008	3	5
BLOOD_Lymphoma	DNAAF4 →	+1.051	+0.219	<.001	<.001	3	5
OESOPHAGUS	B4GAT1 →	+1.078	+0.151	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002639 vs IL17RC — BLOOD_Lymphoma

Explore this scatter interactively →