Regulation of immunoglobulin production

Across TCGA patient cohorts, RNA activity of the Regulation of immunoglobulin production pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, TNFAIP8L2, and FMNL1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of immunoglobulin production activity versus WIPF1 in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WIPF1 →	+0.418	+0.030	<.001	<.001	3	10
GBM	TNFAIP8L2 →	+0.493	+0.031	<.001	<.001	3	10
GBM	FMNL1 →	+0.586	+0.054	<.001	<.001	3	9
LSCC	LCP2 →	+0.496	+0.050	<.001	<.001	3	9
GBM	DOCK2 →	+0.534	+0.051	<.001	<.001	3	9
BRCA	ANKRD44 →	+0.479	+0.038	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0002637 vs WIPF1 — BRCA

Explore this scatter interactively →